Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Progression Free Survival
研究概览
简要总结
The purpose of this study is to evaluate the efficacy of modified FOLFIRINOX followed by stereotactic body radiotherapy (SBRT) in patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC). The primary hypothesis will be to determine if modified FOLFIRINOX followed by SBRT improves progression free survival (PFS) compared to historical controls treated with gemcitabine-based chemotherapy with or without standard fractionated radiation.
详细描述
The Primary and Secondary are listed below.
Primary Objective:
- To evaluate progression free survival after modified FOLFIRINOX and SBRT in borderline resectable and locally advanced pancreatic cancer.
Secondary Objective:
- To evaluate the radiographic response to FOLFIRINOX and SBRT by comparing IV contrast CT scans before and after therapy.
- To determine rates of recurrence (local only, systemic only, and both local and systemic), and overall survival.
- To determine rates of grade 3 or greater gastrointestinal toxicity, including acute toxicities occurring within 3 months of treatment, and late toxicities occurring over 3 months after completion of radiation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed pancreatic adenocarcinoma
- •Borderline resectable pancreatic adenocarcinoma or locally advanced pancreatic adenocarcinoma
- •No evidence of extrapancreatic disease on diagnostic imaging
- •No evidence of invasion into the duodenum or stomach, as determined by EGD/EUS
- •No prior treatment (chemotherapy, biological therapy, or radiotherapy) for pancreatic cancer
- •No prior treatment with oxaliplatin, irinotecan, fluorouracil, or capecitabine
- •ECOG Performance Status of 0-1
- •No other malignancy within past five years (exceptions include basal cell carcinoma of the skin, cervical carcinoma in situ, and non-metastatic prostate cancer)
- •No evidence of second malignancy at the time of study entry
- •No interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
- •No > grade 2 sensory peripheral neuropathy
- •No uncontrolled seizure disorder, active neurological disease, or known CNS disease
- •No significant cardiac disease, including the following: unstable angina, New York Heart Association class II-IV congestive heart failure, myocardial infarction within six months prior to study enrollment
- •Not pregnant and not nursing
- •No other medical condition or reason that, in the opinion of the investigator, would preclude study participation
- •Laboratory parameters as follows:
- •Absolute neutrophil count ≥1,500/uL,
- •Platelet count ≥75,000/uL,
- •Hemoglobin ≥9 g,/dL,
- •Creatinine <1.5 X ULN or estimated GFR >30 ml/min,
- •Bilirubin <1.5 X ULN,
- •AST and ALT <3 X ULN,
- •Negative pregnancy test in women of childbearing potential
- •Able to be treated with SBRT only at the Smilow New Haven campus
- •Able to have fiducials placed in the pancreas
排除标准
- •Failing to meet any of the Inclusion Criteria
研究组 & 干预措施
mFOLFIRINOX followed by SBRT
Patients will receive mFOLFIRINOX, followed stereotactic body radiotherapy (SBRT).
干预措施: mFOLFIRINOX (Drug)
mFOLFIRINOX followed by SBRT
Patients will receive mFOLFIRINOX, followed stereotactic body radiotherapy (SBRT).
干预措施: Stereotactic body radiotherapy (SBRT) (Radiation)
结局指标
主要结局
Progression Free Survival
时间窗: 9 months
Progression-free survival (PFS) at will be judged by CT scan and Response evaluation criteria in solid tumors (RECIST).
次要结局
- Overall Survival(Up to 3 years)
- Radiographic Response(Within 21 days of starting study drug)
- Rates of Recurrence(Up to 3 years)
- Rates of grade 3 or greater gastrointestinal toxicity(Up to 3 months post treatment)