Predective Factors for Tumor Aggressiveness in Medullary Thyroid Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 46
- 主要终点
- Central lymph node metastasis
研究概览
简要总结
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.
详细描述
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients >18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection
排除标准
- •Age < 18 years
结局指标
主要结局
Central lymph node metastasis
时间窗: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Central neck compartment lymph node metastasis
Lateral lymph node metastasis
时间窗: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Lateral neck compartment lymph node metastasis
Distant metastasis
时间窗: Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Liver and lung metastasis
次要结局
- Nuclear atypia as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- White blood cell as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- Amyloid as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- CEA as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- Immunohistochemistry as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- Calcitonin as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- CEA drop as Biochemical cure marker(up to 1 year postoperatively)
- Calcitonin drop as Biochemical cure marker(up to 1 year postoperatively)
- Desmoplasia as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- Platelet count as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
研究者
Papavramidis Theodossis
Associate Professor
Aristotle University Of Thessaloniki