Evaluation of Adipokines ( Ghrelin, Resistin and Adiponectin), in Egyptian Women With Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- serum ghrelin level
研究概览
简要总结
To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).
详细描述
Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital
排除标准
- •Known androgen secreting tumor.
- •PCO on ovarian stimulation medications
- •PCO with any other medical illness.
结局指标
主要结局
serum ghrelin level
时间窗: 24 hours
measuring ghrelin, and ) in the three groups
serum resistin level
时间窗: 24 hours
serum resistin level in the three groups
serum adiponectin level
时间窗: 24 hours
serum adiponectin level in the three groups
次要结局
- serum testosterone level(24 hours after labor)
- Glucose/Insulin ratio(24 hours)
研究者
Ahmed Mohamed El Kotb Abdel Fattah
Lecturer in obstertics and gynecology, Ain Shams University Hospital
Ain Shams University