NCT01682694已完成不适用
Glucosamine and Chondroitin Effects
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- hsCRP
研究概览
简要总结
A common starting dose of glucosamine and chondroitin will reduce inflammation as reflected by a reduction in serum C-reactive protein.
详细描述
Use of glucosamine and chondroitin have been associated with reduced cancer and overall mortality. The aim of this study is to determine whether a common starting dose of glucosamine and chondroitin (1500 mg/d + 1200 mg/d, respectively) reduces systemic inflammation as reflected by a reduction in high sensitivity C-reactive protein.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight (body mass index kg/m2 (BMI) between 25 and 32.5)
- •Non-smoking men and women
- •Aged 20-55y
排除标准
- •Chronic medical illness, history of gastrointestinal, hepatic, or renal disorders, or inflammatory conditions (including autoimmune and inflammatory diseases)
- •Pregnancy or lactation
- •Currently on a weight-loss diet
- •BMI (body mass index) < 25 or > 30
- •Alcohol intake of greater than 2 drinks/day
- •Current use of prescription or over-the-counter medications, (Excluding oral contraceptives and hormone-secreting IUDs), including use of aspirin or NSAIDs more than 2 days per week
- •Abnormal renal, liver or metabolic test
- •Inability to swallow pills
- •Known allergy to shellfish
- •Not willing to take pills made from shellfish or animal sources
- •Intention to relocate out of study area within next 4 months
结局指标
主要结局
hsCRP
时间窗: 1 year
hsCRP is a biomarker of systemic inflammation
次要结局
- untargeted (exploratory) serum metabolomics (differences in small molecule abundance ratios)(1 year)
研究者
研究点 (2)
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