Impacts of a Combined Berry Extract Supplement on Endothelial Function, Blood Pressure, Oxygen Utility Capacity, and Fatigue Index in Healthy Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Endothelial Function
研究概览
简要总结
The purpose of this study is to investigate the impacts of a combined berry extract supplement (hawthorn berry, tart cherry, and bromelain extracts) on total antioxidant capacity, endothelial function, blood pressure, oxygen utility capacity, and fatigue index in healthy young adults.
详细描述
There are several proposed mechanisms that are thought to contribute to the development of cardiovascular diseases. Although the process is extremely complex, it is well-accepted that elevated levels of reactive oxygen species (ROS) production and inflammation contribute to the systemic vascular dysfunction in cardiovascular diseases. These factors often partially contribute to endothelial dysfunction, elevated blood pressure, reduced oxygen utility capacity, and reduced muscle function. Therefore, by reducing ROS and inflammation, there may be protective effects against vascular dysfunction and thus protection against cardiovascular disease manifestation. Intake of natural anthocyanins and polyphenols derived from fruits and vegetables has been shown to reduce excessive ROS and inflammation in several populations.
Therefore, the purpose of this study was to investigate the impacts of a combined berry extract supplement (hawthorn berry, tart cherry, and bromelain extracts) on total antioxidant capacity, endothelial function, blood pressure, oxygen utility capacity, and fatigue index in healthy young adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
Neither the subject nor the investigators were aware of the study assignments, which were assigned by a lab member not directly involved in the measurements of the research.
入排标准
- 年龄范围
- 19 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •otherwise healthy adult
排除标准
- •cardiovascular disease
- •neurological disorder
- •metabolic disorder
- •respiratory disorder
- •renal diseases
- •musculoskeletal injury
- •bleeding disorder
- •allergy to fruit
- •pregnant/breast feeding
- •taking daily medication (prescription or over-the-counter)
研究组 & 干预措施
Placebo intake, then Berry extract intake
Participants received a single dose of placebo (flour capsule). After a washout period of 2 weeks, they then received a single dose of berry extract supplement (hawthorn berry extract, tart cherry extract, and bromelain).
干预措施: Placebo (Other)
Berry extract intake, then Placebo
Participants received a single dose of berry extract supplement (hawthorn berry extract, tart cherry extract, and bromelain). After a washout period of 2 weeks, they then received a single dose of the placebo (flour capsule).
干预措施: Berry extract (Dietary Supplement)
结局指标
主要结局
Endothelial Function
时间窗: 1 day
Endothelial function was measured using flow-mediated dilation in percents (%). A higher value represents a better outcome. Scale range for endothelial function is approximately 8-12% for healthy populations.
次要结局
- Exercise Fatigue Index During Leg Extension(1 day)
- Deoxygenated Hemoglobin(1 day)
- Exercise Fatigue Index During Leg Flexion(1 day)
- Oxygenated Hemoglobin(1 day)
- Oxygen Utility Capacity (Tissue Saturation Index)(1 day)
- Plasma Total Antioxidant Capacity(1 day)
- Systolic Blood Pressure(1 day)
- Diastolic Blood Pressure(1 day)