Impact on Mortality of the Choice Between a Mono- Versus Combination Antibiotic Therapy in Enterococcus Faecalis Bacteremia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Intrahospital all-cause mortality
研究概览
简要总结
Enterococcus faecalis is a germ frequently responsible for bacteremia which can be severe with 15-25% risk of mortality and 26% risk of infectious endocarditis. There is no recommendation for the treatment of "simple" Enterococcus faecalis bacteremia (meaning without infectious endocarditis at diagnosis), nor studies comparing monotherapy versus combination antibiotic therapy.
Our main objective is to study the impact on mortality of bacteriostatic monotherapy and bactericidal combination antibiotic therapy in patients with Enterococcus faecalis bacteremia. We aim to also study the mortality up to three months, the failures of treatment, the modalities of treatment, the renal toxicity and the bacterial resistance.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject of legal age (≥18 years)
- •Having a positive blood culture result for Enterococcus faecalis identified within the microbiology laboratory of the University Hospital of Strasbourg during the period from 01 January 2017 to 31 December 2023.
排除标准
- •Penicillin treatment < 7 days
- •Treatment not containing a penicillin effective against enterococci among those studied: amoxicillin or piperacillin-tazobactam
- •Combination of penicillin with another antibiotic effective against enterococci other than cephalosporins or aminoglycosides (glycopeptides, linezolids, carbapenems, levofloxacin, moxifloxacin).
- •Bacteremia with one or more other pathogens within the first 7 days of bacteremia
- •Infective endocarditis at diagnosis and within the first 7 effective days of treatment
- •Resistance of Enterococcus faecalis to amoxicillin
- •Mortality <72 hours after initiation of antibiotic therapy
- •Lack of information regarding the chosen antibiotic treatment
结局指标
主要结局
Intrahospital all-cause mortality
时间窗: Up to 6 months
次要结局
未报告次要终点