The Impact of Implementing a Hospital-wide Patient Blood Management (PBM) Program on Blood Product Utilization and Maternal Outcomes in All Obstetric Deliveries: a Retrospective Observational Study (2018-2025)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 44,000
- 试验地点
- 1
- 主要终点
- Mean number of blood product units transfused per delivery
研究概览
简要总结
Obstetric anemia and hemorrhage are major causes of maternal morbidity and increased healthcare utilization. Although red blood cell (RBC) transfusion is commonly used, it is associated with higher rates of postpartum complications, including pneumonia, renal failure, and cardiac events (Kloka et al.).
Patient Blood Management (PBM) is an evidence-based approach that aims to optimize a patient's own blood and reduce avoidable transfusion through three pillars: treating anemia and iron deficiency, minimizing blood loss, and avoiding unnecessary transfusion. International guidelines support PBM in obstetrics, but data on comprehensive program implementation remain limited due to barriers such as resource constraints and the need for multidisciplinary coordination.
Aims , objectives and Hypotheses Primary Aim To assess the association between PBM implementation and blood product utilisation among all obstetric deliveries at Corniche Hospital between 2018 and 2025.
Primary Objective To estimate the change over time in the mean number of blood product units transfused per delivery (combined and by product type).
Primary Hypothesis Increasing PBM maturity over time, particularly following comprehensive PBM implementation in 2022, is associated with a significant reduction in mean blood product units transfused per delivery, after adjusting for changes in case-mix.
Secondary Objectives Secondary objectives include evaluating changes in transfusion-related practice and anemia outcomes, including proportion of deliveries receiving any transfusion; pretransfusion hemoglobin thresholds in non-actively bleeding patients (where definable); predelivery anemia prevalence (and iron therapy utilization where captured).
Maternal outcomes will be evaluated by reporting composite morbidity; postpartum hysterectomy; hospital length of stay; High Dependency unit (HDU)/ICU admission and length of stay; 28-day all-cause emergency readmissions; in-hospital mortality. Neonatal outcomes will not be included.
At Corniche Hospital, prior evaluation in cases of major obstetric hemorrhage showed that PBM reduced blood product use and improved hemoglobin recovery without increasing morbidity (Ansari et al.). This study extends the assessment to all deliveries from 2018-2025 to evaluate hospital-wide changes in transfusion practice and maternal outcomes as PBM implementation matured.
详细描述
Aims / Objectives / Hypotheses Primary Aim To assess the association between PBM implementation and blood product utilization among all obstetric deliveries at Corniche Hospital between 2018 and 2025.
Primary Objective To estimate the change over time in the mean number of blood product units transfused per delivery (combined and by product type).
Primary Hypothesis Increasing PBM maturity over time, particularly following comprehensive PBM implementation in 2022, is associated with a significant reduction in mean blood product units transfused per delivery, after adjusting for changes in case-mix.
Secondary Objectives Secondary objectives include evaluating changes in transfusion-related practice and anemia outcomes, including proportion of deliveries receiving any transfusion; pretransfusion hemoglobin thresholds in non-actively bleeding patients (where definable); predelivery anemia prevalence (and iron therapy utilization where captured).
Maternal outcomes will be evaluated by reporting composite morbidity; postpartum hysterectomy; hospital length of stay; HDU/ICU admission and length of stay; 28-day all-cause emergency readmissions; in-hospital mortality. Neonatal outcomes will not be included.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All women delivered at Corniche Hospital during the study period
排除标准
- 未提供
研究组 & 干预措施
All patients delivered between 2018 and 2025
结局指标
主要结局
Mean number of blood product units transfused per delivery
时间窗: 2018 - 2025
measured combined units of RBC, FFP and platelet units measured per delivery
次要结局
- Proportion of deliveries receiving any blood product (RBC/FFP/platelets)(2018-2025)
- Mean pretransfusion Hb in non-actively bleeding patients (where definable)(2018-2025)
- Predelivery anemia prevalence (define threshold consistent with local policy; e.g., Hb <11g/dL)(2018-2025)
- Utilization of IV iron pre- and post-delivery (if available and reliable)(2018-2025)
- Composite morbidity(2018-2025)
- Postpartum hysterectomy (standalone)(2018-2025)
- In-hospital mortality(2018-2025)
- Hospital length of stay (LOS)(2018-2025)
- HDU/ICU LOS (if available)(2018-2025)
- 28-day all-cause emergency readmissions(2018-2025)
研究者
Dr. Tarek Ansari
Head of Anesthesia department
Corniche Hospital
