NCT04450810已完成不适用
Evaluation of Serum and Salivary NLRP3 in Periodontitis and Diabetes Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- Clinical attachment level
研究概览
简要总结
NLRP3 plays a key role in endothelial function and may be a link for the known interaction of periodontitis and diabetes. The investigators compared the impact of gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3levels.
详细描述
The aim of this study was to evaluate a possible association between NLRP3 and gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3 levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Presence of at least 15 teeth
- •CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- •≥2mm and probing depth (PD) ≥4mm;
- •Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- •Presence of ≥40% sites with bleeding on probing (BOP)
排除标准
- •Intake of contraceptives
- •Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- •Status of pregnancy or lactation
- •Previous history of excessive drinking
- •Allergy to local anaesthetic
- •Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
结局指标
主要结局
Clinical attachment level
时间窗: 1-year
evaluation of changes in clinical attachment level
次要结局
未报告次要终点
研究者
Gaetano Isola, DDS, PhD
Researcher
University of Messina
研究点 (1)
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