NL-OMON54496招募中不适用
The Locus coeruleus hits the bull's eye: stress-vulnerability as a predictor for cognitive decline. - Stress, pupils and memory
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •For the healthy participant group:
- •1. No substantial memory complaints (according to the participant)
- •2. Age: between 30 and 95 years old
- •3. Right-handedness
- •4. Informed consent before participation in the study, For the MCI reference
- •group (patients):
- •1. Diagnosis of MCI based on the latest research criteria (clinical assessment
- •at the memory clinic (prof. Frans RJ Verhey): presence of at least a memory
- •impairment, memory complaints expressed by the patient or informant, no
- •problems in daily life functioning, no dementia and presence of biomarkers
- •2. Clinical Dementia Rating score of 0.5 (CDR distinguishes a stage of
- •questionable dementia (CDR 0.5) from people termed healthy (CDR 0) and those
- •with mild dementia (CDR 1)
- •3. Mini-Mental State Examination (MMSE) 23 and being mentally competent (in
- •general, individuals with a MMSE 18 are considered mentally competent)
- •4. Age: between 60 and 85 years old
- •5. Right-handedness
- •6. Informed consent before participation in the study
排除标准
- •1. Reduced vision (glasses with > -6 or +6 corrected)
- •2. Psychoactive medication use
- •3. Abuse of alcohol and drugs
- •4. Cognitive impairment due to alcohol/drug abuse or abuse of other substances
- •5. Below average neuropsychological test results, in accordance with normative
- •data, corrected for age, education and sex (Criterion for healthy participants
- •6. Past or present psychiatric or neurological disorders (major depression,
- •schizophrenia, bipolar disorder, psychotic disorder (or treatment for it),
- •epilepsy, stroke, Parkinson*s Disease, multiple sclerosis, brain surgery, brain
- •trauma, electroshock therapy, kidney dialysis, Menière*s Disease, brain
- •infections) (with exception of AD in the patient group)
- •7. Major vascular disorders (e.g. stroke)
- •8. Heart diseases or pacemakers
- •9. Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal
- •implants, claustrophobia, body tattoos)
- •10. Contraindications for pupil measurements (e.g. Cataracts, Glaucoma,
- •detached retina*s, eye surgery involving the muscle, penetrating eye wounds,
- •use of cholinesterase inhibitors, anticholinergic eye drop use, droopy eyelids
- •preventing eye measurements)
研究者
相似试验
招募中
4 期
Investigation of Locus Coeruleus Function in Sustained AttentionNCT06041048University of California, Davis40
尚未招募
不适用
A study of Greater Occipital Nerve Blockade for the preventive treatment of Chronic MigraineCTRI/2020/07/026709GB Pant hospital
已完成
Unknown
The continuous peripheraI nerve blockade for lower limb surgery (CAREFREE) trial<p>Postoperative pain</p>10009720NL-OMON29369Department of Anesthesiology, Amsterdam UMC, location AMC.44
招募中
不适用
The *Continuous peripherAl neRve blockadE FoR lowEr limb surgEry* (CAREFREE) trialNL-OMON50914Academisch Medisch Centrum42
已完成
不适用
camparative study of 3 indices for prediction of difficulty in laryngoscopyCTRI/2017/08/009360VMMC and Safdarjang hospital240