ACTRN12611000515998已完成3 期
In adults with uncomplicated lower limb cellulitis, does the addition of ibuprofen 400mg three times per day orally for five days to usual antibiotic treatment, compared with an identical placebo, lead to more rapid resolution of inflammation?
Dr Josh Davis0 个研究点目标入组 46 人开始时间: 2011年5月18日最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1) Age >=18 years.
- •2) Uncomplicated lower limb cellulitis or erysipelas.
- •Cellulitis/erysipelas are defined as being present if the diagnosis has been made by an Infectious Diseases registrar or consultant.
- •The following will be considered complicated” and will thus not be eligible: Abscess requiring surgical intervention. Post-operative wound infection. Coexisting deep venous thrombosis. Suspected or proven necrotising fasciitis or gas gangrene. Cellulitis extending superior to the inguinal ligament.
- •3) Admitted directly to the Hospital in the Home unit from the emergency department or a referring GP.
- •4) Receiving intravaneous Cefazolin 2grams every 12 hours
- •5) Able to be randomised within 24 hours of the first dose of effective IV antibiotics.
排除标准
- •1) Allergy to non-steroidal anti-inflammatory drugs including aspirin.
- •2) Definite history of current peptic ulcer or past complicated peptic ulcer.
- •3) Acute renal impairment (Serum Creatinine>120).
- •4) Chronic renal impairment with eGFR<50.
- •5) Current Varicella or zoster infection (chicken pox or shingles).
- •6) Iatrogenic immunosuppression.
- •7) Known pregnancy.
- •8) Currently taking regular anti-inflammatory drugs that cannot be ceased
- •9) Currently taking therapeutic anticoagulation or potent antiplatelet agents
研究者
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