Impact of Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program on Hospitalized Older Patients: A Non-Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Appropriateness of Proton Pump Inhibitors Usage
研究概览
简要总结
To evaluate the impact of clinical pharmacist-led appropriate acid suppression therapy stewardship program in hospitalized older patients.
详细描述
This prospective, nonrandomized controlled study was conducted in older patients who ordered proton pump inhibitor (PPI) at admission in an internal medicine service of tertiary training and research hospital. In the intervention group, clinical pharmacist-led services (including medication reconciliation and medication review) were conducted during hospitalization and at discharge by using the guidelines and potentially inappropriate medications (PIM) criteria [American Geriatric Society-AGS Beers Criteria©, 2019]. Medication Appropriateness Index (MAI), inappropriate PPI cost, and hospitalization for gastrointestinal bleeding within 1 year after discharge were calculated in both groups
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 95 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years old or greater
- •Admitted to the hospital with any reason
- •Ordered at least one PPI dose within 48 hours of admission
排除标准
- •Transferred to another ward (including an intensive care unit)
- •Having active gastrointestinal bleeding
- •Having active malignity
结局指标
主要结局
Appropriateness of Proton Pump Inhibitors Usage
时间窗: during hospital stay, an average of 14 days
The rate of appropriateness use of proton pump inhibitors based on the guidelines at hospital stay
Potentially Inappropriate Proton Pump Inhibitors Usage
时间窗: at discharge, an average of 14 days after admission to hospital
The rate of potentially inappropriate use of proton pump inhibitors based on American Geriatric Society Beers Criteria© 2019
次要结局
- Clinical outcome(1 year)
- Cost saving during hospital stay(during hospital stay, an average of 14 days)
- Medication Appropriateness Index for Proton Pump Inhibitors at hospital stay(during hospital stay, an average of 14 days)
- Cost saving after discharge(a month)
- Medication Appropriateness Index for Proton Pump Inhibitors at discharge(at discharge, an average of 14 days after admission to hospital)
研究者
Betul Okuyan
Assoc.Prof.
Marmara University