Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Healthy
- 发起方
- Thomas Radtke
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Diffusing capacity for nitric oxide (DLNO)
- 状态
- 已完成
- 最后更新
- 5年前
概览
简要总结
This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.
详细描述
The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.
研究者
Thomas Radtke
PD Dr phil Thomas Radtke
University of Zurich
入排标准
入选标准
- •Age 18 yrs and older
- •Ability to follow study procedures and instructions in German
排除标准
- •Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
- •Obesity (BMI \> 30kg/m2)
- •Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
- •Mental impairment leading to inability to cooperate
- •Respiratory infection in the last two weeks
- •Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.
结局指标
主要结局
Diffusing capacity for nitric oxide (DLNO)
时间窗: At third study visit, approximately 1-2 weeks after second study visit
DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.
次要结局
- Alveolar volume (VA)(At third study visit, approximately 1-2 weeks after second study visit)
- Diffusing capacity for carbon monoxide (DLCO)(At third study visit, approximately 1-2 weeks after second study visit)
- Diffusing capacity for nitric oxide (DLNO)(At third study visit, approximately 1-2 weeks after second study visit)
- Breath hold time (BHT)(At third study visit, approximately 1-2 weeks after second study visit)