Brainstem Mapping of Nociceptive Trigeminal Input
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Statistical Parametric Map calculated from the fMRI data in the insula
研究概览
简要总结
To what extent the somatotopy of the 3 branches of the trigeminal nerve (V1,V2,V3) as well as the greater occipital nerve (GON) in the brainstem but also in the thalamus and the insula can be mapped using functional imaging and BOLD in humans is not known but might play an important role in imaging headache diseases. The aim is to map their somatotopy by random stimulation of V1, V2, V3 and the GON with painful electrical input during acquisition of BOLD-fMRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •suitable fo MRI
排除标准
- •headache disease
- •psychological disorder
- •pregnancy
- •all exclusion criteria necessary for imaging in a 3 T MRI scanner
研究组 & 干预措施
Electric Stimulation
干预措施: Electric Current Stimulation (Device)
结局指标
主要结局
Statistical Parametric Map calculated from the fMRI data in the insula
时间窗: through study completion, an average of 9 months
At a statistical threshold of T-value 4 we will observe a somatotopical arrangement in the insula: Expected location for V1: within radius of 10 mm around the MNI coordinates (38,-15,8); Expected location for V2: within radius of 10 mm around the MNI coordinates (37,-8,-5) Expected location for V3: within radius of 10 mm around the MNI coordinates (39,2,-11) Expected location for GON: within radius of 10 mm around the MNI coordinates (38,-12,-3)
Statistical Parametric Map calculated from the fMRI data in the thalamus
时间窗: through study completion, an average of 9 months
At a statistical threshold of T-value 4 we will observe a somatotopical arrangement in the thalamus: Expected location for V1: within radius of 10 mm around the MNI coordinates (11,-5,6); Expected location for V2: within radius of 10 mm around the MNI coordinates (13,-11,5) Expected location for V3: within radius of 10 mm around the MNI coordinates (12,-10,5) Expected location for GON: within radius of 10 mm around the MNI coordinates (15,-12,-7)
Statistical Parametric Map calculated from the fMRI data on brainstem level
时间窗: through study completion, an average of 9 months
At a statistical threshold of T-value 3 we will observe a somatotopical arrangement in the brainstem below the pons: Expected location for V1: within radius of 10 mm around the MNI coordinates (-1,-48,-75); Expected location for V2: within radius of 10 mm around the MNI coordinates (-4,-47,-69) Expected location for V3: within radius of 10 mm around the MNI coordinates (-1,-46,-66) Expected location for GON: within radius of 10 mm around the MNI coordinates (-1,-45,-64)
次要结局
- Statistical Parametric Map calculated from the fMRI data in the periaqueductal gray (PAG)(through study completion, an average of 9 months)
- Statistical Parametric Map calculated from the fMRI data in the cerebellum(through study completion, an average of 9 months)