Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial) Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Change in healing
研究概览
简要总结
Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction. Because of the repair abilities of the growth factors and proteins released by platelets, the development and application of platelet-enriched preparations have revolutionised the area of regenerative medicine.The present study will be designed to study the difference between A-PRF and IPRF with the addition of Xenograft in the preservation of bone in mandibular molars.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who need extraction of hopeless mandibular molars
- •Teeth with advanced caries not amenable for conservative treatment
- •Patients who are willing and fully capable of complying with the study protocol.
排除标准
- •Systemic diseases that prevent surgery
- •Acute or chronic oral infections
- •Periodontal diseases
- •Heavy smokers or alcoholics
- •On anticoagulant drugs.
- •Pregnancy
- •History of radiotherapy or chemotherapy of the head and neck region
研究组 & 干预措施
Control
干预措施: Control (Other)
A-PRF
干预措施: A-PRF (Other)
I-PRF
干预措施: I-PRF (Other)
结局指标
主要结局
Change in healing
时间窗: Baseline and 12 weeks
A modified Landry, Turnbull, and Howley healing index will be used to assess wound healing (HI). This entails evaluating the following parameters in a comparative manner using a dichotomic score (1/0). Tissue colour or the presence or absence of redness to indicate inflammatory processes; granulation tissue; suppuration; swelling; degree of tissue epithelialisation (partial or complete); and the presence or absence of bleeding and tenderness on palpation
change in bone density
时间窗: Baseline and 12 weeks
Bone density will be measured using CBCT examinations
次要结局
未报告次要终点
研究者
Hams Hamed Abdelrahman
Lecturer of Dental Public Health and biostatistical consultanat
Alexandria University