CTIS2022-503089-57-00招募中1 期
Exploratory study of the expression of the serotonergic 5-HT4 receptor in Parkinson's disease - 69HCL22_0953
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 35
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Clinically established or probable diagnosis of Parkinson's disease according to the criteria defined by the Movement Disorder Society at a Hoehn and Yahr stage = 3 (for patient only), Duration of disease progression between 2 and 8 years (for patient only), MoCA = 20/30 (for patient only), Age between = 50 and = 85 years old, if woman , postmenopausal woman, Affiliated to a social security scheme or similar, Having given their written consent to participate, Level of study: = 6 years of schooling, No history of neurological or psychiatric disease (healthy volunteers only)
排除标准
- •Diagnosis other than Parkinson's disease ( for patient only), Deprivation of liberty by judicial or administrative decision, person subject to a legal protection measure, BMI = 35kg/m2, Presence of depression (BDI-2 score =21), anxiety (Parkinson Anxiety Scale, PAS score =14) or apathy (STARKSTEIN score =14) - for healthy volunteers only, Cognitive impairment (MOCA score =26) (for healthy volunteers only), Current or past neurological or psychiatric pathology (for healthy volunteers only), Serious and progressive medical pathology, Treated with specific serotonin inhibitors (SSRIs), specific noradrenaline inhibitors (SNRIs), tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs) and neuroleptics in the last 3 months, Use of recreational drugs interfering with the serotonergic system (ecstasy, MDMA) or opioids (cannabis, opiates) in the last 3 months or chronic use, Contraindication to magnetic resonance imaging (MRI) or positron emission tomography (PET), Participation in the last year to a study using ionizing radiation or concomitant participation in another research project involving the human being that may interfere with the results or the conclusions of this study, Exceeding the annual amount of compensation authorized for participation in research protocols
研究者
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