Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- changes in pH and independent pH determinants using Stewart approach
研究概览
简要总结
The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.
详细描述
Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L).
Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •serum albuminemia < 20g/L
- •adult ICU patient
- •Arterial line
排除标准
- •albumin allergy
- •pregnancy
- •congestive heart failure
结局指标
主要结局
changes in pH and independent pH determinants using Stewart approach
时间窗: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.
次要结局
- changes in hemodynamic parameters(at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.)
- changes in respiratory parameters(at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.)
- changes in neurologic parameters(at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.)