NCT00826163已完成3 期
Innate Immune Responses in Chronic Obstructive Pulmonary Disease Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Sputum IL-8, IL-17
研究概览
简要总结
We hypothesize that ongoing and more severe airway inflammation in COPD may result from the impairment in activation of innate immune response
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of COPD or asthma
- •a ratio of prebronchodilator FEV1 to forced vital capacity (FVC) equal to or less than 0.70
- •postbronchodilator FEV1 > or = 50% predicted
排除标准
- •Exacerbation
- •systemic corticosteroids
- •DM, HIV and autoimmune disease
- •immunosuppressive therapy
研究组 & 干预措施
stable COPD
Active Comparator
Postbronchodilator FEV1> or = 50% predicted
干预措施: Budesonide (Drug)
Asthma
Sham Comparator
Postbronchodilator FEV1 > or = 50% predicted
干预措施: Budesonide (Drug)
结局指标
主要结局
Sputum IL-8, IL-17
时间窗: 2 WEEKS
次要结局
- The expression of NF-kappa B in sputum macrophages(2 WEEKS)
研究者
Kittipong Maneechotesuwan
Professor
Mahidol University
研究点 (1)
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