Drug-drug interaction study to explore importance of CYP3A4 and OATP1B1 as factors determining pharmacokinetics of atorvastatin - Drug-drug interaction study on atorvastatin

Clinical trial Center,Kitsato University East Hospital0 个研究点目标入组 8 人开始时间: 2009年9月10日最近更新: 2023年10月17日

适应症

试验速览

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•1)Any hypersensitivities to atorvastatin,midazolam,pravastatin, straconazole or rifampicin. 2)hepatic disease requiring treatment. 3)acute narrow-angle glaucoma 4)QT prolongation over 460ms. 5)Use of medicine or health product including Saint John's wort 2 weeks before pre-dose. 6)Intake of fruit food and drink including grapefruit juice, orange juice or apple juice from 7 days before pre-dose. 7)Participation to any other clinical reseach in the past 3 months. 8)Donating over 200 ml of blood in the past 1 month or over 400ml of blood in the past 3 months. 9)Positive tests of serological reaction for syphilis, HIV antigen and antibody, HBs antigen or HCV antibody. 10)Any allergy to drug and food 11)Drug abuse or positive drug screening 12)Any condition that, in the opinion of the investigator, would make the patient unsuitable for the study.

发起方

Clinical trial Center,Kitsato University East Hospital