Study of the Association Between Renal Reserve Function and Progression of Renal Function to Predict Chronic Kidney Disease Risk in Thai Elderly
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change of renal functional reserve per 12 months (mL/min)
研究概览
简要总结
This study investigates renal functional reserve in elderly.
详细描述
The prevalence of CKD in elder is high as age has been a variable in eGFR equation. eGFR by calculation always declines in parallel with age. The assumption that a persistent over 3 months of eGFR less than 60 mL/min/1.73m2 define CKD with risk of progression and need refer to nephrologist may not necessary true in aging population. We study renal functional reserve in elderly population who risk of CKD progression and ESRD is the highest prevalence in human life cycle and explore whether renal functional reserve can be used as ad additional marker of CKD progression in elderly.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient age > 60 years at screening
- •Patient willing to participate in the study and can provide inform consent
- •Patient have residual kidney function ≤ 90 ml/min/1.73m2 by CKD-EPI equation
排除标准
- •Patient active smoking
- •Patient have Charlson comorbidity index > .....
- •Patient active cancer
- •Patient contraindications for blood collection
- •Patients with a history of hypersensitivity to cimetidine or amino acid IV solution
结局指标
主要结局
Change of renal functional reserve per 12 months (mL/min)
时间窗: 12 months
Renal functional reserve defined as the difference between baseline creatinine clearance and creatinine clearance achieved under stimulation with amino acid infusion.
次要结局
未报告次要终点
研究者
Kearkiat Praditpornsilpa
Professor of Medicine
Chulalongkorn University