BEAT CF: Pulmonary Exacerbations Treatment Platform - Backbone Antibiotics Domain:An evaluation of the comparative effectiveness of prescribing various standard of care, first-line Backbone Antibiotics in the management of pulmonary exacerbations requiring intensive therapy (PERIT) in children and adults with CF, with respect to their short-term improvement in lung function.

niversity of Sydney0 个研究点目标入组 500 人开始时间: 2022年7月5日最近更新: 2024年4月8日

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•1. Be enrolled in the BEAT CF PEx Cohort (ACTRN12621000638831).
•2. Documented informed consent to participate in the Backbone antibiotics Domain.
•3. Are eligible for at least two Interventions in the Backbone Antibiotic Domain available at the clinical Site.
•4. Must be able to reliably perform spirometry.

•1. The person is unable to reliably perform spirometry (for example due to young age)
•2. The person’s Responsible Clinician deems enrolment in the PEx Backbone Antibiotic Domain is not in their best interest.
•A participant will be excluded from Assignment to a specific Intervention in the Backbone Antibiotics Domain if:
•1. They have a known or suspected significant drug hypersensitivity to that antibiotic
•2. They have another recognised contraindication to that antibiotic
•3. The Intervention is deemed unacceptable by the Responsible Clinician e.g. because of a poor treatment response to that antibiotic (requiring a change in antibiotic treatment) in the preceding 12 months

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