inking protein profiles to disease progression and clinical expression in Parkinson*s disease: part two, longitudinal outcomes - PROGRESS-PD

Vrije Universiteit Medisch Centrum0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•* Patients from the baseline cohort diagnosed with Parkinson*s disease according to the MDS Clinical Diagnostic Criteria for Parkinson*s Disease
•* Mini-Mental State Examination (MMSE) score *18 at recruitment
•* Being able to understand the aim of the study and the study procedure and give written informed consent

•* A history of neurological disorders other than PD, that affect the central nervous system or are known to influence CSF proteins
•* Unwillingness to be informed of unexpected medical findings;Potential subjects are eligible to participate in this study if they cannot undergo lumbar puncture due to the following reasons:
•* No CSF collected at baseline
•* Use of anticoagulants or a history of coagulation disorders
•* Infected skin over the needle entry site for lumbar puncture
•* Signs of raised intracranial pressure
•* Travelling to the VUmc outpatient clinic is too burdensome
•* Unwillingness to undergo lumbar puncture
•These subjects we will undergo all study procedures with the exception of CSF collection.

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