NCT04212182Unknown不适用
The Physiological Effect of High Flow Oxygen Therapy on Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The First Affiliated Hospital of Guangzhou Medical University1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2019年12月27日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Neural respiratory drive
研究概览
简要总结
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AECOPD patients with acute hypercapnic respiratory failure
排除标准
- •other lung/pleural diseases or thoracic deformity
- •severe heart failure (New York Heart Association class IV), severe dysrhythmia
- •unstable angina, or malignant comorbidity
- •obesity (BMI ≥ 35 kg/m²)
- •severe obstructive sleep apnea syndrome
结局指标
主要结局
Neural respiratory drive
时间窗: 30 minutes
Neural respiratory drive is calculated by diaphragm electromyogram
次要结局
- Work of breathing(30 minutes)
- Transcutaneous CO2(30 minutes)
研究者
Rongchang Chen
Principal Investigator
The First Affiliated Hospital of Guangzhou Medical University
研究点 (1)
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