Effect of Beetroot Juice Consumption on Endothelial Function and Tissue Oxygen Saturation in Pregnant
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- Macro endothelial function
研究概览
简要总结
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blind
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •gestation between 20 and 35 weeks;
- •over 18 years
排除标准
- •diabetes mellitus and gestational diabetes;
- •hypertensive syndromes;
- •HIV positive;
- •liver or kidney disease;
- •beetroot allergy;
- •use of antioxidants and medicament that alter endothelial function;
- •use of antibiotics up to 2 weeks before the visits and using.
研究组 & 干预措施
Beetroot Juice
Beetroot juice containing 9 mmol of nitrate per dose
干预措施: Beetroot juice (Other)
Placebo juice (nitrate depleted)
Beetroot juice nitrate-depleted
干预措施: Placebo (Other)
结局指标
主要结局
Macro endothelial function
时间窗: Evaluated 120 minutes after the nutritional intervention
Flow-mediated dilation (FMD)
Micro endothelial function
时间窗: Evaluated 140 minutes after the nutritional intervention
Tissue oxygen saturation parameters
Nitrate urinary
时间窗: Evaluated 150 minutes after the nutritional intervention
次要结局
未报告次要终点
研究者
Thiago Alvares
PhD
Universidade Federal do Rio de Janeiro