ACTRN12617000213347已完成1 期
Does nifedipine improve implantation and pregnancy rates in women undergoing in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles?
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 93
研究概览
简要总结
o statistical differences in the implantation rate and the clinical pregnancy rate were detected between the placebo and the treatment groups. In addition, no statistical significance between the placebo and the treatment groups for any secondary outcomes were detected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 45 Years（—）
- 性别
- Female
入选标准
- •* 18-45yo females undergoing IVF/ICSI cycles with either fresh or frozen embryo transfer.
- •* Baseline Blood Pressure: greater than, or equal to, 100/60, measured prior to ET
排除标准
- •*Body mass index (BMI) > 38 kg/m2
- •*Early follicular phase (day 2-4) serum follicle stimulating hormone (FSH) level > 20 mIU/ml.
- •*Abnormal uterine cavity as evidenced by sonohysterogram or hysterosalpingography
- •*Any contraindication to being pregnant and carrying a pregnancy to term.
- •* Contraindication for the use of nifedipine, Estrogen and Progesterone suppositories.
- •* Patient being treated with other drugs that interact with cytochrome P450 activity: azole antifungals, cimetidine, cyclosporine, erythromycin, quinidine, terfenadine, warfarin, benzodiazepines, flecainide, imipramine, propafenone and theophylline.*Irregular heart beat or already being treated with another medication for high blood pressure.
- •*Any ovarian or abdominal abnormality that may interfere with adequate transvaginal sonography (TVS) evaluation.
- •*Administration of any investigational drugs within three months prior to study enrollment.
- •*Patient not able to communicate adequately with the investigators and to comply with the requirements of the entire study.
- •*Unwillingness to give written informed consent.
- •*Previous entry into this study.
- •*BP <100/60
研究者
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