JPRN-jRCTs041180085已完成未知
The effects of anaglipitin, a DPP-4 inhibitor, on blood lipids in type 2 diabetic patients. - ANGELS
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 24
研究概览
简要总结
This study showed that the DPP-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels, suggesting that this drug may have beneficial effects on lipid metabolism possibly mediated by the inhibition of intestinal lipid transport.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- over 20 至 ot applicable（—）
- 性别
- All
入选标准
- •Type 2 diabetes
- •HbA1c >= 6.5%
- •Serum LDL >= 120 mg/dl
- •No DPP4 inhibitors for latest 3 months
- •No antidiabetic medication or no change in medication for the latest 3 months
- •20 y.o. or older
- •Written agreement is obtainable from the patient
排除标准
- •Type 1 diabetes
- •Treatment with insulin, glinides, high doses of SU
- •Patients with repetitive or unaware severe hypoglycemia
- •Severe liver diseases
- •Patients with hemodialysis
- •Severe cardiac diseases or acute myocardial infarction within 6 months
- •Severe anemia
- •Severe pancreatitis
- •Malignant diseases
- •Uncontrolled endocrine diseases
- •Severe infections or surgical treatment
- •Severe diabetic complications
- •Severe bowel diseases
- •Alcohol addiction
- •Pregnant or possibly pregnant women
- •History of allergic reaction to DPP4 inhibitors
- •Patients who a physician-in-charge considers is unsuitable for the trial.
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