Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Spectometry to measure hemoglobin rate
研究概览
简要总结
The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.
The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
- •Subjects will have to sign the inform consent before the beginning of the study
排除标准
- •Contraindications to regular physical exercise practice
- •To practice an endurance sport more than 1h/week
- •Regular practice of apnea
- •Chronic use of cannabis and/or alcohol
- •Cardiac or metabolic pathology
- •Asthma and/or bronchodilatator treatment
- •ECG abnormality at rest
- •Regular consumption of tobacco
研究组 & 干预措施
Apnea Group (GApn)
Program of training with exercises including apneas
干预措施: Program of training with exercises including apnea (Other)
Control Group (GC)
Program of training with exercises without apnea
干预措施: Program of training with exercises without apnea (Other)
结局指标
主要结局
Spectometry to measure hemoglobin rate
时间窗: 3 weeks
Measurement of oxygenation
Wingate test to measure maximum consumption of dioxygen
时间窗: 3 weeks
Measurement of aerobic performance
Measurement of hormonal markers
时间窗: 12 weeks
Measurement of Dehydroepiandrostenedione (DHEA)
Jaeger debimeter system to measure of peak oxygen
时间窗: 12 weeks
Measurement of oxygen consumption,
Spectometry to measure hemoglobin
时间窗: 12 weeks
Measurement of oxygenation
Measurement of arterial saturation in dioxygen
时间窗: 12 weeks
Measurement by ear blood micro-sample
Measurement of hormonal markers
时间窗: 3 weeks
Measurement of Dehydroepiandrostenedione (DHEA)
Jaeger debimeter system to measure of peak oxygen
时间窗: 3 weeks
Measurement of oxygen consumptiom
Measurement of arterial saturation in dioxygen
时间窗: 3 weeks
Measurement by ear blood micro-sample
次要结局
- Cardiac frequency(12 weeks)
- Borg scale to measure penibility of the effort(week 12)
- Cardiac frequency(3 weeks)
- Borg scale to measure penibility of the effort(week 3)