IRCT20151227025726N29招募中2 期
Evaluation of the Effects of Tocilizumab Administration in the Cytokine Release Phase on the CT Scan Findings and Clinical Outcomes in Hospitalized COVID-19 Patients
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 70 years（—）
- 性别
- All
入选标准
- •Patients between 18 and 70 years old
- •Laboratory confirmed COVID-19 with RT-PCR
- •Be in severe or critical stage of the disease
- •Have interleukin-6 levels above 15 picogram per milliliter or CRP above 100 miligram per liter
排除标准
- •Acute or chronic renal failure (Increase in creatinine by more than 3.0 in the last 48 hours or GFR less than 30 mL/min)
- •Liver failure (more than 5-fold increase in liver enzymes in asymptomatic patients or more than 3-fold increase in liver enzymes in symptomatic patients or Child Pugh C, D)
- •Hypersensitivity reaction during tocilizumbe injection with severe extrusion and symptoms of anaphylactic shock
- •Mild stage of the disease
- •Pregnant and lactating patients
- •Patients with platelets less than 100,000 or ANC less than 5
- •Patients with Latent TB or Active TB or any active infection
- •History of active gastric ulcer
- •Patients with positive viral marker
研究者
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