REMISE Study: REMnant Biospecimen Investigation in SEpsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 71
- 试验地点
- 1
- 主要终点
- Difference in traditional biomarkers, proteomics, pathogen sequencing, and metabolomics/lipidomics between prospectively collected biospecimens and remnant biospecimens.
研究概览
简要总结
In the REMISE is study, we will compare blood proteins, biomarkers, and other -omics prospectively collected from patients with sepsis from two sources, i.) remnant (discarded) samples from the clinical laboratory, and ii.) prospectively collected in UPMC Presbyterian hospital research coordinator specimen collected biospecimens.
Analyses will include traditional biomarkers, quantitative proteomics, metabolomics, lipidomics, transcriptomics, and pathogen genomic sequencing in both sets of samples. This data will allow the assessment of the feasibility, integrity, and scientific value of remnant samples compared to research coordinator samples collected at the bedside for mechanistic sepsis research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient, at least 18 years of age
- •Meeting Sepsis-3 criteria within 6 hours of admission
- •Biospecimens obtained for routine clinical care and measurement
- •Peripheral intravenous access
排除标准
- •Patients who do not have Sepsis-3
- •Traumatic injury,
- •Inability to consent or contact legal representative,
- •Cardiac arrest,
- •Comfort measures only,
- •Unable to obtain intravenous access, and/or
- •Subject declines to participate.
- •No residual blood left in clinical sample
结局指标
主要结局
Difference in traditional biomarkers, proteomics, pathogen sequencing, and metabolomics/lipidomics between prospectively collected biospecimens and remnant biospecimens.
时间窗: 01/2024
次要结局
- Measurement of traditional biomarkers in all samples(1/2024)
- Measurement of metabolomics/lipidomics in all samples(1/2024)
- Measurement of proteomics in all samples(1/2024)
- Pathogen sequencing in all samples(1/2024)
研究者
Christopher Seymour
Associate Professor, Dept. of Critical Care Medicine, University of Pittsburgh School of Medicine Associate Professor, Depts. of Emergency Medicine & Clinical Translational Science The CRISMA Center, Director, Translational and Clinical Science Program
University of Pittsburgh