Identification of High-Risk Patients at Admission to an Emergency Department by Non-Invasive Hemodynamics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 942
- 试验地点
- 1
- 主要终点
- 30-day mortality and/or acute deterioration.
研究概览
简要总结
The goal of this study is to evaluate the prognostic values of non-invasive hemodynamic parameteres in relation to 30-day mortality and/or acute deterioration in patients who are admitted acutely to the department of emergency medicine or cardiology.
详细描述
Background
Identification of critically ill and high-risk patients at hospital admission is a major triage task in the emergency department. Rapid identification and treatment of such patients improves survival, reduces complications during admission, duration of hospitalization and the costs of treatment. Reduced heart rate variability (HRV), a marker of autonomic imbalance towards sympathetic dominance, has been shown in several studies to be associated with a poor prognosis in patient groups like myocardial infarction, heart failure, ischemic heart disease, and others. Besides HRV other hemodynamic variables like cardiac stroke volume, cardiac output and peripheral resistance will potentially improve diagnosis of critically ill patients by providing better prognostic value.
Aims & objectives
To develop and validate a prognostic model (based on selected variables derived from Finapres measurements, HRV, CO, and TP) for 30-day mortality and/or acute deterioration in patients who are admitted acutely to the department of emergency medicine or cardiology, University Hospitals of Bispebjerg & Frederiksberg
Methods & Materials
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Admittance with acute illness at the department of medicine/emergency medicine / Cardiology at Bispebjerg Hospital
- •Able to give informed consent
排除标准
- •Terminal disease like advanced cancer or advanced organ failure with a life expectancy of less then three months.
- •Candidate for immediate intensive care therapy
- •Refuse or unable to give consent
结局指标
主要结局
30-day mortality and/or acute deterioration.
时间窗: 30 days from inclusion
Death within 30 days and/or cute deterioration in term of unplanned hospital admissions or unplanned transfer to the intensive therapy or any higher level of care.
次要结局
- 90-day primary outcome(90 days from inclusion)
- Major Cardiovascular Events (MACE)(30 days from inclusion)
- MACE 90-days(90 days from inclusion)
研究者
Ahmad Sajadieh
Associate professor
University Hospital Bispebjerg and Frederiksberg