A Novel Neurobehavioral Intervention for Emotion Regulation in Anxiety and Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 4
- 主要终点
- Distal outcomes
研究概览
简要总结
The research proposes to use an innovative solution to shape brain circuits that support executive function and emotion reactivity -using targeted neurobehavioral intervention.
详细描述
Participants will be recruited locally in the San Francisco Bay area with certain symptoms of anxiety and depression. They will complete a clinical assessment and then take part in a cognitive-emotion training delivered online.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of depression on the SCID, a total Ham-D≥16 and Ham-D anxiety/somatization subscale ≥ 7.
排除标准
- •Current medication for psychiatric disorders
- •Pregnant females
- •Head trauma or injury that resulted in loss of consciousness
- •MRI contraindication
研究组 & 干预措施
Computerized intervention
Participants will be asked to visit a customized website and engage in computerized exercises. Cognitive and emotion training games.
干预措施: Computerized neurobehavioral intervention (Behavioral)
Control
Participants will be asked to visit a customized website and engage in computerized games.
干预措施: Computerized neurobehavioral intervention (Behavioral)
结局指标
主要结局
Distal outcomes
时间窗: 5 months
We anticipate that anxiety and depression symptoms, explicit emotion regulation capacities and quality of life reported on self-report measures will show improvement.
Completion
时间窗: 60 days
We anticipate that participants will complete at least 30-days of the intervention.
Proximal outcomes
时间窗: 60 days
We anticipate that proximal measures of symptoms will show improvement following the training in terms of emotional reactivity, implicit emotion regulation, negative emotional memory bias, attentional bias for threat, executive functions behaviorally and N-back during fMRI as well as resting-state fMRI connectivity.
次要结局
未报告次要终点
研究者
Amit Etkin
Principle Investigator
Stanford University