ISRCTN01500324已完成不适用
Prevention of Atrial Arrhythmias by Infusion of Magnesium Sulphate after Lung Resection for Cancer
Record Provided by the NHSTCT Register - 2007 Update - Department of Health0 个研究点目标入组 240 人开始时间: 2007年9月28日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •240 subjects will be recruited. The investigator will be responsible for screening all patients listed for lung surgery at the CTC. Evidence from Terzi et al [32], had demonstrated that incidences of AF occurred in 10.7% of patients on magnesium sulphate as compared with 26.7% of control patients. We predict that at 90% power (2-sided ¿=0.05), 240 patients allowing for drop outs, deaths etc) are required to detect at least a 16% reduction in incidences of AF. Inclusion Criteria:
- •1. Elective for non-cardiac thoracic operations for lung cancer (lobectomy and pneumonectomy)
- •2. Ability to provide informed consent
排除标准
- •1. Patients not undergoing major lung resection (see above)
- •2. Impaired renal function, preoperative creatinine >200 mol/L
- •3. Myocardial infarction within the last 6 months
- •4. Urgent or emergency operations
- •5. Video assisted thoracic surgery
- •6. Currently on drugs with antiarrhythmic properties
- •7. Patients with a history of preoperative cardiac arrhythmias
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