Effects of Ketogenic Diet on Muscle Hypertrophic Response to Resistance Exercise
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- mammalian target of rapamycin (mTOR) signalling
研究概览
简要总结
The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •at least 2 years of resistance-training experience
- •Body mass index: more than 18 kg/m2 and less than 30 kg/m2
排除标准
- •metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc)
- •experience with the ketogenic diet (last six months)
- •acute inflammatory status
- •treatment with steroids in the past 3 months
研究组 & 干预措施
ketogenic diet
Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).
干预措施: resistance training (Other)
ketogenic diet
Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).
干预措施: ketogenic diet (Other)
western diet
Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).
干预措施: resistance training (Other)
western diet
Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).
干预措施: western diet (Other)
结局指标
主要结局
mammalian target of rapamycin (mTOR) signalling
时间窗: Change from baseline to 4 weeks
Measurement of the change in muscle protein anabolic signalling pathway in response to a single bout of resistance exercise by western blot analysis.
次要结局
- Skeletal muscle mass(Change from baseline to 4 weeks)