NL-OMON54480尚未招募不适用
Induction of neo*antigen specific cytotoxic T cells by autologous tumor lysate-loaded specialized cross*presenting dendritic cells in epithelial ovarian cancer patients treated with neoadjuvant chemotherapy, the NEODOC study - NEOadjuvant Dendritic cell vaccination for Ovarian Cancer (NEODOC)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age over 18 years old
- •Histologically confirmed primary epithelial ovarian cancer
- •Not amenable by primary debulking surgery and in need of neoadjuvant
- •chemotherapy and interval debulking
- •High-grade serous histology
- •FIGO stage IIIb, IIIc, IVa or IVb if only lymph nodes <= 1cm above the
- •diaphragm or in the groins
- •Extensive abdominal spread of tumor
- •WHO/ECOG performance status 0-1
排除标准
- •Recurrent ovarian cancer
- •History of any second malignancy, with the exception of adequately treated
- •basal cell carcinoma, cervical cancer > 5 years ago or early stage breast
- •cancer >10 years ago.
- •Any serious clinical condition that may interfere with the safe
- •administration of DC vaccinations or renders patient ineligible for combined
- •carboplatin-paclitaxel chemotherapies
- •Active infection of Hepatitis B, C, HIV and syphilis or any other serious
- •active infection
- •Known allergy to shell fish
- •Auto immune disease (exception: vitiligo is permitted)
- •Chronic treatment with systemic immunosuppressive drugs (i.e. more than 10 mg
- •prednisolone equivalent)
研究者
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