NL-OMON22602尚未招募不适用
A phase I/II trial towards the safety and efficacy of preemptive vaccination with PD-L silenced, minor histocompatibility antigen UTA2-1 peptide-loaded Dendritic Cells after Allogeneic Stem Cell Transplantation
VU University Medical Center0 个研究点目标入组 17 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 17
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients with Multiple Myeloma (MM) or Chronic Lymphocytic Leukemia (CLL) or non hodgkin lymphoma (any grade) or acute myeloid leukemia (AML)
- •2. Recipient and donor have a mismatch in UTA2-1 mHag in the Graft versus Tumor (GvT) direction (recipient UTA2-1 positive, donor UTA2-1 negative).
- •4. Recipient and donor are positive for HLA-A*0201
- •5. Age 18-75 years
- •6. Absence of acute GvHD > grade 2 or extensive chronic GvHD
- •7. No treatment with immunosuppressive drugs such as prednisone, cyclosporine A and MMF at least 4 weeks prior to planned vaccination date.
- •8. WHO performance 0-2
- •9. Absence of severe cardiac hepatic, renal, or metabolic disease
- •10. Written informed consent
排除标准
- •1. WHO performance 3-4
- •2. Presence of severe cardiac hepatic, renal, metabolic disease
- •3. Rapidly progressive disease,
- •4. Life expectancy < 3 months
研究者
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