Effects of Moderate-intensity Interval Aerobic Exercise (MIIAE) on Inflammatory, Immune, Metabolic, Physical Fitness, and Quality of Life Parameters in Breast Cancer Patients Undergoing Radiotherapy.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
研究概览
简要总结
Breast cancer and its treatment with radiotherapy may be associated with systemic inflammatory, hematological, cardiac, body composition, functional and quality-of-life alterations. Exercise has emerged as a non-pharmacological strategy with potential benefits during oncological treatment; however, further evidence is needed regarding the effects of supervised moderate-intensity interval aerobic exercise during radiotherapy.
This randomized controlled trial aims to evaluate the effects of a supervised moderate-intensity interval aerobic exercise programme on systemic inflammatory and immune-derived hematological indices, cardiac biomarkers, body composition, muscle strength, lower-limb power, sleep quality and breast cancer-specific quality of life in women with breast cancer undergoing radiotherapy.
Participants will be allocated to either an experimental group performing supervised moderate-intensity interval aerobic exercise during radiotherapy or to a control group receiving usual care without structured exercise during the study period. Outcomes will be assessed at baseline and after completion of the intervention period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged between 20 and 65 years.
- •Clinical diagnosis of breast cancer (Stage I-III).
- •Patients who have undergone lumpectomy or mastectomy.
- •Scheduled to start radiotherapy treatment.
- •Sedentary lifestyle according to international physical activity guidelines.
- •Ability to understand and follow instructions.
- •Ability to provide written informed consent.
排除标准
- •Presence of infectious disease.
- •Cardiovascular or respiratory disease.
- •Metastatic disease.
- •Uncontrolled diabetes mellitus.
- •Neuropathy.
- •Physically active individuals meeting WHO physical activity recommendations.
- •Participation in an exercise intervention program within the last 3 months.
- •Any condition that, in the opinion of the research team, may compromise safety or participation.