The Effectiveness of Emergency Room Protocols for Treating Hyperthermia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Rectal temperature cooling rate
研究概览
简要总结
This study will help us as scientists and clinicians understand how effective commonly used cooling protocols in emergency departments are and which of the protocols is the most effective.
It consists of a single, approximately 1 hour preliminary session and five, approximately 3 hour experimental sessions, equaling an approximate 16 hour total time commitment.
The purpose of this research is to test the effectiveness of three cooling protocols.
- Cooling packs
- "Ice Sheets", which are bed sheets soaked in ice water, wrapped around the participant, while a fan blows air on them.
- Body bag filled with ice, commonly used in emergency departments to treat hyperthermia
Additionally, a negative control (passive cooling in air-conditioned room) and a positive control (cold water immersion).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Active, healthy individuals
排除标准
- •Pregnant or planning on becoming pregnant
- •Have a pacemaker
- •Currently taking any prescribed or over the counter medications or nutritional supplements known to influence thermoregulatory responses
- •Experience lingering pain from a previous musculoskeletal injury (i.e. knee, hip, or back pain)
- •Use tobacco/nicotine products
研究组 & 干预措施
Passive cooling
Participant lies supine in an air-conditioned room
干预措施: Passive cooling (Procedure)
Cooling packs
During recovery, cooling packs are applied on either side of the neck, both underarms, and both sides of the groin
干预措施: Cooling packs (Procedure)
Ice sheets
During recovery, participants lie supine and are wrapped in bed sheets that have been soaked in ice water, then have a fan directed towards them while cooling
干预措施: Ice sheets (Procedure)
Body bag full of ice
During recovery, participants are zipped into a body bag that is full of ice
干预措施: Body bag cooling (Procedure)
Cold water immersion
During recovery, participants are submerged to the neck in a cold water bath
干预措施: Cold water immersion (Procedure)
结局指标
主要结局
Rectal temperature cooling rate
时间窗: The measurement occurs immediately upon completion of the exercise protocol. Time itself is part of the outcome variable and will vary between participants (~3 to 40 min post exercise protocol).
Following termination of the exercise protocol, at a core temperature above 39 degrees Celcius, participants will be cooled until they reach a core temperature of 38 degrees Celcius. The cooling rate in degrees Celcius per minute, is the primary outcome.
次要结局
未报告次要终点
研究者
Nathan Morris
Assistant professor
University of Colorado, Colorado Springs