Assessment of Darvyadi Niruhabasti & Panchatikta Panchaprasrutik Basti in the management of Kitibha Kushtha w.s.r. to Psoriasis - A comparative clinical trial

Psoriasis is one of the most common dermatological diseases affecting 2% of the World’s population. In India, the prevalence of Psoriasis varies from 0.44% to 2.8%. To date, no proper curative measures are found to treat psoriasis in modern science, so it is necessary to find a safe and effective measure for Psoriasis. Psoriasis has maximum resemblance with the Kitibha kushtha mentioned as a type of Kushtha in Ayurvedic classics so can be treated as per Kushtha chikitsa. As per Ayurveda’s unique treatment, Basti karma here is an attempt to study the efficacy of  Darvyadi Niruhabasti and Panchatikta Panchaprasrutik Basti with Madanadi taila Anuvasana Basti in the management of Kitibha Kushtha (Psoriasis).

RESEARCH QUESTION:

Whether the Darvyadi Niruhabasti & Panchatikta Panchaprasrutik Basti with Madanaditaila Anuvasanabasti are effective in the Yogabasti krama in the management of Kitibha kushtha w.s.r. to psoriasis?

AIM:

Comparison of the efficacy of Darvyadi Niruhabasti & Panchatikta Panchaprasrutik Basti along with Madanaditaila Anuvasanabasti in the management of Kitibha kushtha.

OBJECTIVES:

• To determine the effects of Darvyadi Niruhabasti and Madanaditaila Anuvasanabasti in the management of Kitibha kushtha.
• To determine the effects of Panchatikta Panchaprasrutik Basti and Madanaditaila Anuvasanabasti in the management of Kitibha kushtha.
• To compare the efficacy of Darvyadi Niruhabasti & Panchatikta Panchaprasrutik Basti along with Madanaditaila Anuvasanabasti in the management of Kitibha kushtha.
• To evaluate the role of Basti treatment in the management of Kitibha kushtha.

MATERIALS AND METHODS:

• Duration of Study: 18 months
• Study design: Randomized comparative clinical trial
• Purpose of the study will be explained and written informed consent will be taken from every patient.
• SOURCES OF DATA:

1. LITERARY SOURCE: All classical, modern literature and contemporary texts including the journals and websites about the disease, drugs and procedures will be reviewed and documented for the study.
2. PHARMACEUTICAL SOURCE: Madanaditaila for Anuvasanabasti will be prepared in the GMP certified Pharmacy of Parul Institute of Ayurveda. Niruhabasti will be prepared at Parul Ayurveda Hospital as per proper SOPs.
3. CLINICAL SOURCE: Diagnosed cases of Kitibha kushtha, will be selected from OPD and IPD of Parul Ayurveda Hospital, Limda, Vadodara.

TREATMENT GROUPS:

Group A (Trial group) – 20 patients will be administered Darvyadi Niruhabasti and Madanaditaila Anuvasanabasti.

Group B (Control group) – 20 patients will be administered Panchatikta Panchaprasrutik Basti and Madanaditaila Anuvasanabasti.

SUBJECTIVE CRITERIA –

• Shyavavarna
• Kinkhara sparsha
• Parushatva
• Kandu
• Scaling

OBJECTIVE CRITERIA –

• Auspitz sign
• Candle Grease test
• PASI Score

INTERVENTION:

• Yoga Basti: 8 days

1st day 2nd day 3rd day4th day 5th day6th day 7th day8th day
AB NBABNBABNBABAB

Here, AB - Anuvasana Basti, NB - Niruha Basti

• Basti Quantity: 1. Niruha Basti - 550 ml 2. Anuvasana Basti - 70 ml
• Follow up - 15 days after treatment of 8 days

The effect of the Basti (Panchakarma therapy) will be assessed based on the following criteria – 

• Samyak Basti Lakshanas
• The retention time of Basti
• Number of purisha vega
• Possible complications after administration of Basti
• Vital data of patients