NMDA Antagonist Efficacy in Reducing Human Alcohol Consumption: Impact of Family History
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Baseline-adjusted Craving (YCS)
研究概览
简要总结
The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ages 21-50
- •Able to read English at 6th grade level or higher and to complete study evaluations
- •Regular alcohol drinker
排除标准
- •Individuals who are seeking alcohol treatment
- •Medical conditions that would contraindicate the use of memantine
- •Regular use of other substances
研究组 & 干预措施
1
20 mg memantine
干预措施: Memantine (Drug)
2
40 mg memantine
干预措施: Memantine (Drug)
3
干预措施: Placebo (Drug)
结局指标
主要结局
Baseline-adjusted Craving (YCS)
时间窗: Day 7
Craving for alcohol based on Yale Craving Scale, scores ranging from 0-112 mm on a visual analog scale, with higher measurements indicating higher craving. The baseline-adjusted craving is change score from baseline at Day 7.
Number of Drinks Consumed on Day 7
时间窗: Day 7
次要结局
- Stimulation Responses to Alcohol(Day 7)
- Sedation Responses to Alcohol(Day 7)