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临床试验/NCT04301960
NCT04301960已完成不适用

Comparison of the Effects of Single and Dual Task Training on Processing Speed, Cognitive Functions, Walking Speed, Dual Task Performance and Balance Functions in Individuals With Mild Cognitive Impairment

Eastern Mediterranean University1 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2021年2月16日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
42
试验地点
1
主要终点
Choice Stepping Reaction Time Test (CSRT)

研究概览

简要总结

The aim of this study is to compare the effects of single and dual-task training on processing speed, cognitive functions, walking speed, dual-task performance and balance functions in individuals with mild cognitive impairment.

详细描述

Mild Cognitive Impairment (MCI) is a cognitive impairment that usually occurs with the normal cognitive decline with age and does not significantly affect daily function. MCI is diagnosed by the presence of one or more cognitive deficits that occur without meeting the diagnostic criteria of dementia. MCI is regarded as an intermediate stage between normal cognition and dementia. Also known as the early stage of dementia. Although 6 main cognitive domains could potentially be affected (learning and memory, social functioning, language, visuospatial function, complex attention, or executive functioning), the term "mild cognitive impairment" generally refers to a decline in the ability to learn new information or recall stored information. While the current dementia criteria require that cognitive functions be impaired to prevent an individual from continuing his/her daily life independently, MCI is the stage where there is no significant problem in the daily life of the individual before this stage. Risk factors include male sex, presence of the apolipoprotein E allele, family history of cognitive impairment, and the presence of vascular risk factors such as hypertension, hyperlipidemia, coronary artery disease, and stroke.

Training of cognitive functions with physiotherapy can be effective in improving various aspects of objective cognitive functioning (memory performance, executive functioning, processing speed, attention, fluid intelligence, and subjective cognitive performance). It has been reported that there is a slowdown or decrease in cognitive status through training. In the literature, there were no studies comparing single and dual-task training effects in patients with mild cognitive impairment. Therefore, the aim of this study is to compare the effects of single and dual-task training on the processing speed, cognitive functions, walking speed, dual-task performance and balance functions in individuals with mild cognitive impairment.

Participants who are between the ages of 65-85, who has Montreal Cognitive Assessment score between 13-26, the Quick Mild Cognitive Impairment Screen score between 48-67, Instrumental Activities of Daily Living Scale score ≥6/8, who says yes to "Do you have a memory problem?", who can walk independently without using any walking aids and who are likely to be MCI as a result of the tests will be referred to the neurologist and those whose diagnosis is confirmed will be included in this study. Participants who have any musculoskeletal disorders that may cause balance and gait disorders, central or peripheral neurological diseases (eg. stroke, Parkinson's disease or polyneuropathies), using psychiatric drugs that may affect psychiatric disease and / or cognitive performance, daltonism diagnosed and who attending any exercise program will not be included in this study.

All the participants will be measured with Choice Stepping Reaction Time (CSRT) Test, Stroop Test, backward counting, verbal fluency, 10 meters walking test (10MWT), 10MWT with backward counting and verbal fluency for dual tasking, Fullerton Advanced Balance (FAB) Scale and D+R Balance Application. The measurements will be made at the beginning of the treatment (0 week) and at the end of the treatment (8 weeks).

The choice stepping reaction time (CSRT) task has been better to discriminate between fallers and non-fallers than other sensorimotor and balance measures and to predict falls in older people, mediated through physiologic and cognitive pathways.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
65 Years 至 85 Years(Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Participants who are between 65-85 years of age,
  • •Who has the Montreal Cognitive Assessment score between 13-26,
  • •Who has the Quick Mild Cognitive Impairment screen score between 48-67,
  • •Who has Instrumental Activities of Daily Living Scale score ≥6/8,
  • •Who says yes to "Do you have a memory problem?" question,
  • •Who can walk independently without using any walking aids and
  • •Who is likely to have mild cognitive impairment as a result of the tests will be referred to the neurologist and those whose diagnosis is confirmed will be included in this study.

排除标准

  • •Participants who have any musculoskeletal disorders that may cause balance and gait disorders,
  • •Who have central or peripheral neurological diseases (eg. stroke, Parkinson's disease or polyneuropathies),
  • •Who are using psychiatric drugs that may affect psychiatric disease and/or cognitive performance,
  • •Who has daltonism and
  • •Who attends any exercise program will not be included in this study.

研究组 & 干预措施

Single task group

Experimental

The single task group includes balance gaining and cognitive training. The single task group will have 30-40 minutes of single-task training for 3 sessions per week for 8 weeks.

干预措施: Single task training (Other)

Dual-task

Experimental

The dual-task group includes CSRT Mat training. The dual-task group will have CSRT Mat training for 30-40 minutes of dual-task training for 3 sessions per week for 8 weeks.

干预措施: Dual task training (Other)

结局指标

主要结局

Choice Stepping Reaction Time Test (CSRT)

时间窗: 8 weeks

A custom-made Choice Stepping Reaction Time step pad (CSRT-MAT) and a computer unit will be used to evaluate the processing speed. The system is consisted of a CSRT-MAT having pressure-sensitive panels and a display monitor connected to a computer unit. The computer unit recorded the timing of foot lift and landing. The step direction is indicated by one arrow changing its color. The CSRT device included 2 tests: Stepping Reaction Time (SRT) and Stroop Test (ST). In this study, only the SRT test will be done. In the SRT test, the participants are asked to step as quickly as possible onto the corresponding arrow on the CSRT-MAT and then return to the center. The reaction time (RT) measured from stimulus occurrence to movement initiation (lift off), movement time (MT) measured from movement initiation to step finalization (step down) and total response time (RsT) measured as the sum of RT and MT.

次要结局

  • Stroop Test(8 weeks)
  • Verbal Fluency Test (VFT)(8 weeks)
  • Serial Subtraction Test (SST)(8 weeks)
  • 10 Meter Walking Test (10 MWT)(8 weeks)
  • 10 Meter Walking Test with Verbal Fluency Test (10 MWT-VFT)(8 weeks)
  • 10 Meter Walking Test with Serial Subtraction Test (10 MWT-SST)(8 weeks)
  • Fullerton Advanced Balance (FAB) Scale(8 weeks)
  • D+R Balance Application(8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Betül Fatma Bilgin

Research assistant

Eastern Mediterranean University

研究点 (1)

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