Transit Time Flow Measurement in Coronary Surgery: The Mutual Influence of Collateral Flow Between Different Coronary Territories on Parameter Metrics
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- LIMA>LAD Pulsatility index (PI) modification
研究概览
简要总结
Transit-time flowmetry (TTFM) allows grafts quality control during coronary artery bypass surgery by measuring the flow volume through them.
To date, many studies have deeply studied the predictive role on the graft outcomes of the various flowmetry-derived parameters. One of the least investigated aspects, however, is the mutual influence that two newly realized grafts can have. This possibility would be related to the presence of a more or less developed collateral circulation between the bypassed territories.
The purpose of this study is to assess whether a graft for a territory different than that provided by the left anterior descending artery (LAD) may affect the functionality (measured through flowmetry) of the left internal mammary artery - LAD graft.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18 years;
- •informed consent acquired and registered;
- •patients who undergo coronary artery bypass grafting (with or without cardiopulmonary bypass);
- •patients with stable angina, unstable angina or acute coronary syndrome without elevation of the ST tract (NSTEMI)
排除标准
- •patients unable to give informed consent;
- •patients undergoing emergency surgery;
- •patients in unstable haemodynamic conditions or in need of pharmacological or mechanical support;
- •patients undergoing combined surgery;
- •patients undergoing single aortocoronary bypass surgery
结局指标
主要结局
LIMA>LAD Pulsatility index (PI) modification
时间窗: During the surgery, out of cardiopulmonary bypass
The primary aim of this study is to assess whether a graft for a non-LAD coronary target modifies the performance (measured by flowmetry) of the flow in the LIMA\>LAD graft. PI is expressed by the ratio of the flow volume amplitude and mean flow volume, both quantified by a flowmeter (ml/min / ml/min). An ideal value would be \< 3
次要结局
- LIMA>LAD Diastolic filling (%DF) change(During surgery,before and after transient occlusion of the other grafts for non-LAD coronary targets.)
- variation of Diastolic filling (%DF) on the right coronary(During surgery,before and after transient occlusion of the other grafts for non-LAD coronary targets.)
- LIMA>LAD % Backward flow (BF) change(During surgery, before and after transient occlusion of the other grafts for non-LAD coronary targets.)
- LIMA>LAD mean flow change(During surgery, before and after transient occlusion of the other grafts for non-LAD coronary targets)
- mean flow, Pulsatility Index, Diastolic filling (%DF) and Diastolic filling (%DF) in the non-LAD grafts(During surgery, before and after transient occlusion of the LIMA>LAD graft)
研究者
Federico Cammertoni
Doctor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS