The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Redistribution of splanchnic blood flow in the vessel mesenteric superior artery (functional MRI)
研究概览
简要总结
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with type 2 diabetes.
详细描述
Each participant will attend four independent randomised experimental days in the MRI-scanner with intravenous infusion (hormone/placebo) and oral ingestion (glucose/water): An intravenous infusion of saline or GIP(3-30)NH2 starts at time point -20 minutes.The infusions are combined with an oral glucose tolerance test (75 gram of glucose dissolved in 250 ml water ingested orally) at time point 0 minutes on two of the experimental days (with and without GIP(3-30)NH2).
MRI measurements are repeatedly performed and blood samples are drawn to be analysed for endocrine responses from the intestines, pancreas, and bones.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes
- •BMI 20-35 kg/m^2
- •Age 20-80
排除标准
- •Not MRI-compatible implants
- •Claustrophobia
- •Abnormal kidney or liver function
- •Planned weight loss or change in diet
- •Hypertension
- •Other conditions that could be expected to affect the primary or secondary outcomes
研究组 & 干预措施
Saline and oral water (SAL-WAT)
Saline infusion, oral water ingestion
干预措施: Saline / placebo (Other)
Saline infusion and oral glucose ingestion (SAL-GLU)
Saline infusion, oral glucose ingestion
干预措施: Saline / placebo (Other)
GIP(3-30)NH2 infusion and oral water ingestion (GIA-WAT)
GIPR antagonist infusion, oral water ingestion
干预措施: GIPR antagonist / study tool (Other)
GIP(3-30)NH2 infusion and oral glucose ingestion (GIA-GLU)
GIPR antagonist infusion, oral glucose ingestion
干预措施: GIPR antagonist / study tool (Other)
结局指标
主要结局
Redistribution of splanchnic blood flow in the vessel mesenteric superior artery (functional MRI)
时间窗: 80 minutes
Measued with phase-contrast MRI in ml/min
次要结局
- GIP(3-30)NH2 levels(80 minutes)
- Glucose(80 minutes)
- C-peptide(80 minutes)
- Glucagon(80 minutes)
- Insulin(80 minutes)
- Blood flow in portal vein(80 minutes)
- Blood flow in hepatic artery(80 minutes)
- Blood flow in coeliac trunc(80 minutes)
- GIP levels(80 minutes)