Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- ELISA tests
研究概览
简要总结
Toxoplasmosis affects one to two newborn each 10000 births. Among them, 1 to 2 % develop learning disabilities or die, and 4 to 27 % develop a chorioretinitis sometimes leading to an amblyopia responsible for visual impairment. Toxoplasmosis uveitis affects too adults immunocompetent and immunodepressed who have had an acquired toxoplasmosis. Clinical diagnosis of ocular toxoplasmosis is more complicated in presence of posterior neuro-retinitis, inflammation of the papilla, uveitis without chorioretinitis, fuchs heterochromic iridocyclitis, scleritis, diffuse necrotizing or multifocal retinitis. In this situation biological markers diagnostic and prognostic of toxoplasmosis uveitis are useful.
Highly kept molecules (during evolution) like stress proteins (Hsp) are are found in the host and the pathogen and there can trigger a crossed immune response. Stress proteins haven't been explored yet, in the context of toxoplasmosis uveitis on humans.
The hypothesis is that Hsp70 and antibodies anti-Hsp70 are diagnostic and prognostic markers of ocular toxoplasmosis.
The goal is to evaluate diagnosis value of biological markers (Hsp70 and antibodies IgG anti-Hsp70) in toxoplasmosis uveitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 接受健康志愿者
- 否
入选标准
- •Age over 18 years
- •Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
- •Persons affiliated to national social security
排除标准
- •Pregnant, parturient or breastfeeding women
- •Persons deprived of liberty by judicial or administrative decision, person under legal protection
- •Refusal by a patient to do the PCA (anterior chamber puncture)
- •Patients whose following will be difficult or nonexistent
研究组 & 干预措施
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Fluorescein angiography (Other)
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Dilated fundus examination (Other)
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Toxoplasmosis serology (Biological)
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Anti-toxoplasmosis treatment (Drug)
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Anti-inflammatory treatments (Drug)
Subjects suspected of toxoplasmosis chorioretinitis infection
Subjects clinically suspected at least of one active source of toxoplasmosis chorioretinitis infection
干预措施: Puncture in anterior chamber (Other)
结局指标
主要结局
ELISA tests
时间窗: About an hour
ELISA (enzyme linked immunosorbent assay) tests. Biological markers evaluation : stress protein Hsp70 and antibodies anti-Hsp70.
次要结局
未报告次要终点