To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Time in seconds to AiO2 from 90 to 40%
研究概览
简要总结
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the "laser mode" is activated on the Monsoon jet ventilator. Ventilation is continued during "laser mode."
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.
- •18 years or older
- •Need rigid bronchoscopy as pre-determined by the interventional pulmonologist
排除标准
- •Refusal to sign consent
- •Pregnant patients
- •Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm
- •Respiratory instability defined as SpO2<90% with >90% supplemental oxygen.
- •Ineligible for rigid bronchoscopic intubation
- •Latex allergy
- •Evidence of fistulous airway
- •Active Bronchopleural fistula
结局指标
主要结局
Time in seconds to AiO2 from 90 to 40%
时间窗: baseline
Time in seconds to AiO2 from 90 to 40% after activating laser mode on the monsoon jet ventilator.
次要结局
- Differences in time to laser mode AiO2(baseline)
