Biomarker Identification for aGVHD After Allogeneic Stem Cell Transplantation: a Multiple Center Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- incidence of grade II-IV aGVHD
研究概览
简要总结
This is a prospective study in patients receiving allogeneic stem cell transplantation. The blood samples on Day-14, -7, 0 and every 7 days until D100 were collected together with clinical data. In the final analysis, cytokines and biomarkers analysis will be carried out and compared between patients in No aGVHD and grade II-IV aGVHD.
详细描述
This is a prospective study, observation study in patients receiving allogeneic stem cell transplantation in 4 BMT centers in Shanghai. The blood samples (on Day-14, -7, 0 and every 7 days until D100) and clinical data will be collected. In the final analysis, a panel of cytokines and biomarkers analysis of serial blood samples will be carried out and compared between patients with no aGVHD and grade II-IV aGVHD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients undergoing allogeneic stem cel transplantation
- •with informed consent
- •patients survived without aGVHD or relapse and patients with development of grade II-IV aGVHD
排除标准
- •patients with blood sample and clinical data not available
结局指标
主要结局
incidence of grade II-IV aGVHD
时间窗: 100 days after allogeneic stem cell tansplantation
clinical diagnosis and grade of aGVHD
次要结局
未报告次要终点
研究者
Jiong HU
Deputy director, department of hematology, Rui Jin Hospital
Shanghai Jiao Tong University School of Medicine