A Double Blind, Double Dummy, Randomized, Two Way Cross-over Study to Compare the Effects of Seretide® Evohaler (Supplied by Allen & Hanburys, UK) and a Generic Salmeterol/Fluticasone HFA pMDI (Manufactured by Cipla Ltd, India) on Functional Respiratory Imaging Parameters in Asthmatic Patients.

FLUIDDA nv1 个研究点分布在 1 个国家目标入组 16 人开始时间: 2013年3月最近更新: 2013年9月19日

适应症

干预措施

试验速览

阶段: 3 期
状态: 已完成
发起方
入组人数: 16
试验地点: 1
主要终点: Total airway volume

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study will be conducted as a randomized, double blind, double dummy two period crossover study in stable asthma patients. A total of 16 stable asthma patients treated in accordance with the Global Initiative for Asthma (GINA) guidelines, will be included.

Objectives:

The primary objective of this study is to evaluate the effect of both the study drugs under investigation on Functional Respiratory Imaging (FRI) parameters and to evaluate the particle deposition in the lungs using Computational Fluid Dynamic (CFD)
The secondary objectives are to assess the effect of both the study drugs on lung function (spirometry and body plethysmography), on exercise capacity (6 Minutes Walking Test = 6MWT) and on dyspnea (Borg Category (C) Ratio (R) 10 Scale and Visual Analog Scale (VAS) dyspnea). Furthermore the safety of the 2 products under investigation will be evaluated through monitoring of adverse events (AEs) throughout the study.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Treatment
盲法: Triple (Participant, Care Provider, Investigator)

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Male or female patient ≥ 18 years old
•Written informed consent obtained
•Patient with a documented diagnosis of asthma according to the GINA guidelines
•Patient with a co-operative attitude and ability to be trained to correctly use the pMDI
•Female patient of childbearing potential who confirm that a contraception method was used at least 14 days before visit 1 and will continue to use a contraception method during the study
•Patient must be stable and treated in accordance with the GINA guidelines
•Patient must be a non-smoker or ex-smoker who have stopped smoking at least 1 year prior to visit 1 and has a smoking history of < 10 pack years
•Patient must be able to understand and complete the protocol requirements, instructions, questionnaires and protocol-stated restrictions

排除标准

•Pregnant or lactating female
•Unstable patient who developed an exacerbation during the last 8 weeks
•Patient with upper or lower airways infection
•Patient unable to carry out pulmonary function testing
•Patient with an uncontrolled disease or any condition that might, in the judgement of the investigator, place the patient at undue risk or potentially compromise the results or interpretation of the study
•Patient with cancer or any other chronic disease with poor prognosis and /or affecting patient status
•Patient with allergy, sensitivity or intolerance to study drugs and/or study drug formulation ingredients
•Patient unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study
•Patient who received oral corticosteroids within the last 4 weeks prior to visit 1
•Patient who received any investigational new drug within the last 4 weeks prior to visit 1 or twice the duration of the biological effect of any drug (whichever is longer)
•Patient with a history of alcohol or substance abuse that in the opinion of the investigator may be of clinical significance
•Patient who has undergone major surgery in the last 12 weeks before the visit 1 or has planned to undergo a major surgery before the end of the trial
•Patient with diagnosis of chronic obstructive pulmonary disease (COPD)

研究组 & 干预措施

Seretide Evohaler

Active Comparator

Salmeterol xinafoate and Fluticasone propionate combination HFA pMDI (Seretide Evohaler, Allen & Hanburys, UK)