Contribution of Corticospinal and Reticulospinal Mechanisms to Neural Adaptations Induced by Muscle Strengthening of Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 22
- 主要终点
- the change in maximum force achieved during a maximal voluntary contraction (MVC) of plantar flexion (the primary action of the triceps surae muscles).
研究概览
简要总结
This controlled trial aims to investigate the neural adaptations induced by a 4-week resistance training program targeting the triceps surae muscles. Specifically, the study will examine the contribution of the corticospinal and reticulospinal pathways to the nervous adaptations associated with resistance training. It will give us more information about the nervous pathways mediating adaptations following this type of training. The main question it aims to answer is: What is the contribution of the cortico- and reticulospinal tracts to the nervous adaptations following a resistance training program?
Participants will take part to a resistance training program of the triceps surae for 4 weeks. They will undergo assessments of corticospinal and reticulospinal excitability before and after the training intervention to determine changes in neural pathways
The findings will improve our understanding of the neural mechanisms underlying strength gains following resistance training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female participants aged 18 to 40 years
- •Willing and able to provide written informed consent
- •No regular participation (>1 session per week) in resistance training aimed at increasing maximal strength
- •Affiliated with, or beneficiary of, a social security system
排除标准
- •Personal or family history of epilepsy
- •Conditions associated with a significantly reduced seizure threshold, including sleep deprivation, extreme fatigue, or jet lag
- •Use of medications or substances known to lower the seizure threshold
- •Use of medications that may influence neurophysiological measures (e.g., neuroleptics, anxiolytics, antidepressants, anticonvulsants)
- •Presence of cardiac pacemakers or other implanted devices that may interfere with magnetic fields
- •Presence of metallic implants (mechanical or electronic), including cochlear implants, cranial implants, cardiac or neural stimulators, drug infusion pumps, magnetic aneurysm clips, or cerebrospinal fluid shunts
- •Presence of non-removable metallic objects
- •Presence of intraocular or intracranial metallic foreign bodies
- •Known hearing disorders (e.g., tinnitus)
- •History of psychiatric or neurological disorders
- •Presence of severe cardiac or respiratory disease
- •History of severe traumatic brain injury with loss of consciousness
- •History of brain lesions of vascular, tumoral, infectious, or metabolic origin (e.g., stroke)
- •History or presence of bleeding disorders (e.g., venous or arterial thrombosis, thrombophlebitis)
- •Individuals currently under an exclusion period from another research study
- •Individuals listed under Articles L.1121-5 to L.1121-8 and L.1121-12 of the French Public Health Code, including:
- •Pregnant, parturient, or breastfeeding women
- •Women of childbearing potential not using effective contraception
- •Individuals deprived of liberty by judicial or administrative decision
- •Adults under legal protection (guardianship, curatorship, or legal safeguard) or unable to provide consent and not under such protection
研究组 & 干预措施
Resistance training group
干预措施: Resistance training (Behavioral)
结局指标
主要结局
the change in maximum force achieved during a maximal voluntary contraction (MVC) of plantar flexion (the primary action of the triceps surae muscles).
时间窗: At baseline (before the first exercise session) and immediately after completion of the exercise sessions
The maximum force, achieved during a maximal voluntary contraction (MVC), will be recorded using an isokinetic ergometer (Biodex Medical Systems Inc., Shirley, NY, USA).
次要结局
- The changes in the amplitude of electrophysiological responses evoked by magnetic or electrical stimulation at different levels of the neuromuscular system (cortical, thoracic, peripheral nerve).(During intervention)