NCT05601557尚未招募不适用
Research on the Clinical Characteristics and Key Diagnosis and Treatment Technology of Genetic and Metabolic Liver Disease
Sujun Zheng0 个研究点目标入组 480 人开始时间: 2022年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 480
- 主要终点
- death
研究概览
简要总结
- Establish a follow-up cohort of genetic and metabolic liver disease in The Chinese population, and carry out research on disease spectrum, clinical characteristics and personalized diagnosis and treatment to improve the level of diagnosis and treatment.
- Establish a multidisciplinary collaborative diagnosis and treatment model of genetic metabolic liver disease, develop and promote diagnosis and treatment paths, and improve the diagnosis and treatment ability of genetic metabolic liver disease in Beijing and even the whole country.
- Establish a new CRISPR gene diagnosis technology to realize fast and low-cost genetic testing.
- Elucidating the genetic mutation spectrum of common genetic and metabolic liver disease in China is helpful to accurate gene diagnosis and functional research.
- Study the genotype-phenotype, mutation and clinical outcome relationship and influencing factors of the common genetic and metabolic liver disease population in China, to guide the early diagnosis, early treatment and improve the prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Meet the diagnostic criteria of each disease.
排除标准
- •Co-infected with hepatitis B virus, hepatitis C virus and HIV;
- •Patients with liver fibrosis and cirrhosis caused by other causes;
- •Patients with alcoholic liver disease and autoimmune liver disease;
- •Liver malignancy has been suggested or confirmed by evidence;
- •Combined with other serious systemic diseases.
结局指标
主要结局
death
时间窗: 5 years
Death during the study was the outcome event
次要结局
未报告次要终点
研究者
Sujun Zheng
Ethics Committee Member
Beijing YouAn Hospital
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