VCRC Tissue Biorepository Collection Protocol
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 8
- 主要终点
- Identify genes that increase the risk of developing vasculitis
研究概览
简要总结
The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.
详细描述
Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).
排除标准
- •Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
- •Unwilling to allow the use of their tissue for research.
结局指标
主要结局
Identify genes that increase the risk of developing vasculitis
时间窗: 1 year
Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis.
次要结局
未报告次要终点
研究者
Peter Merkel
Chief, Division of Rheumatology Professor of Medicine and Epidemiology
University of Pennsylvania