Effect of Oral ATP on Human Muscle Performance
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Work Performed
研究概览
简要总结
Adenosine-triphosphate (ATP) serves as the sole energy source for muscle contraction. Therefore human performance of brief maximal exercise is limited, in part, by the availability of ATP to the contracting muscle. Because muscle ATP storage is small (enough to sustain maximal exercise for less than 1 second), factors that enhance either storage or resynthesis of ATP may have a positive impact on repeated muscle contractions. The current study will test the hypothesis that increasing ATP availability to muscle via oral supplementation will improve performance of repeated high intensity exercise as measured by a) work performed in each of the three 50 contraction fatigue tests, b) sum of total work performed, and c) percentage decrement in total work from the first to third third 50 contraction test.
详细描述
To date we have studied 10 subjects who have followed through with all 3 of the original interventions (Placebo, 250 mg PeakATP/d and 400 mg PeakATP/d). Currently we have received approval and are expanding the study with 5 additional subjects who will receive the Placebo, 400 mg PeakATP/d and the 400 mg PealATP/d plus proprietary blend interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No major medical conditions;
- •Able to perform fatigue testing procedures;
- •Not currently taking prescription medications;
- •Not currently taking dietary supplements (a daily multi-vitamin not exceeding RDA is permitted)
排除标准
- •Major medical condition affecting metabolism or general function;
- •Not able to perform fatigue testing;
- •Taking prescription medications;
- •Taking a dietary supplement other than a multi-vitamin not exceeding RDA
结局指标
主要结局
Work Performed
时间窗: Measured after 15 days of intervention
The work and total work performed in 3 exercise fatigue tests given after 15 days of nutritional intervention.
次要结局
- Decrease in work performed in each successive test(Measured after 15 days of intervention)