Feasibility and Effectiveness of Computerized Cognitive Training in Adolescents With Autism Spectrum Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- Cambridge Neuropsychological Test Automated Battery (CANTAB)
研究概览
简要总结
The investigators will conduct a randomized placebo-controlled trial of a computerized intervention targeting cognition in 30 teens with autism spectrum disorder.
详细描述
Given the limited options for treatments to improve the core symptoms of autism spectrum disorder (ASD), strategies that could target secondary features of the condition and improve quality of life for affected individuals are critical. Neuroplasticity-based cognitive training has been found to improve cognition in youth with attention deficit hyperactivity disorder (ADHD) and in adults with schizophrenia. In this trial, the investigators are seeking to extend the relevance of computerized cognitive training to youth with ASD. Given the literature, the investigators hypothesize that computerized cognitive training will produce gains in untrained cognitive tasks and behavioral ratings of executive functions in youth with ASD. The investigators will assess aspects of attention and executive functions in 30 affected youth and randomize them 1:1 to either neuroplasticity based cognitive tests or enjoyable age-appropriate computer games not intended to improve cognition. Cognition will be assessed again after 15 hours of training over 6 weeks and then again at a three month follow up.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 13 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 ASD or previously diagnosed DSM-IV autistic disorder, Asperger's disorder or pervasive developmental disorder not otherwise specified (NOS) and who continue to manifest symptoms in core domains
- •Current ASD symptomatology at time of enrollment
- •Evidence of decrements in at least one of three target cognitive domains (mental flexibility/abstraction, working memory, or attention).
排除标准
- •Intellectual Disability
- •A known comorbid neurodevelopmental disorder with possible association with autism (i.e., fragile X syndrome, tuberous sclerosis, Angelman syndrome, Prader-Willi syndrome, Williams syndrome, neurofibromatosis, mitochondrial disorder).
- •Nonverbal or minimal verbal ability
- •No computer/internet connection at home
- •No family member with e-mail
- •Patients likely to have a change in therapeutic treatments within the next 6 weeks
研究组 & 干预措施
Cognitive Training
Targeted Cognitive Training (TCT)
干预措施: Targeted Cognitive Training (TCT) (Behavioral)
Control Condition
Youth appropriate online games
干预措施: Youth Appropriate Online Games (Other)
结局指标
主要结局
Cambridge Neuropsychological Test Automated Battery (CANTAB)
时间窗: 6 weeks
Computerized test
次要结局
未报告次要终点
研究者
Alysa Emily Doyle, PhD
Assistant Professor of Psychiatry
Massachusetts General Hospital